One of the largest studies gauging the effect of medical cannabis on patients with MS was one of 630 participants conducted by Zajicek et al. in 2003 at 33 centers. Results showed that participants who used whole-plant cannabis-based medicine (CBM) extracts did not experience an improvement in objective measurements of spasticity measured by the Ashworth scale – a tool used to assess objective measures of spasticity, including tone, resistance, and rigidity in body extremities.
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